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OSHA 1910.1200AppC

Hazardous chemical label elements

Subpart Z

50 Questions & Answers
10 Interpretations

Questions & Answers

Under 1910.1200(C.1) and C.1.1, what product and contact information must appear on a hazardous chemical label for shipped containers?

The label must show the product identifier and the manufacturer's (or importer/responsible party's) name, address, and telephone number for shipped containers. This is required by C.1 and C.1.1 of Appendix C to 1910.1200.

  • The product identifier must match the one used on the Safety Data Sheet (C.1).
  • For shipped containers, include name, full address, and a telephone number of the chemical manufacturer, importer, or responsible party (C.1.1).
  • This information helps users and first responders identify the chemical and obtain emergency information quickly.

Under 1910.1200(C.2), which standardized label elements must appear on a label for a classified hazardous chemical?

A label for each classified hazardous chemical must include the specified signal word, hazard statement(s), pictogram(s), and precautionary statement(s). This requirement is set out in C.2 of Appendix C to 1910.1200.

  • Signal word: either "Danger" or "Warning" as prescribed for the hazard category.
  • Hazard statement(s): standardized text communicating the nature and severity of the hazard.
  • Pictogram(s): selected from the standardized set shown in Appendix C.
  • Precautionary statement(s): guidance on prevention, response, storage, and disposal related to the hazard.

These elements must appear except in limited cases described in the following subsections of Appendix C.

Under 1910.1200(C.2.1), how do precedence rules affect which signal words and pictograms appear on a label?

If higher-priority elements apply, lower-priority ones must be omitted—e.g., if the signal word "Danger" is used, "Warning" must not appear; similarly some pictograms replace others. These precedence rules are specified in C.2.1 of Appendix C to 1910.1200.

  • C.2.1.1: If "Danger" appears, do not also use "Warning".
  • C.2.1.2–C.2.1.4: If a higher-priority pictogram (e.g., skull and crossbones, corrosive, health hazard for respiratory sensitization) applies, the exclamation mark pictogram must be omitted when it would otherwise indicate the same hazard.

Follow these precedence rules so labels show the clearest, most severe indicators without redundancy.

Under 1910.1200(C.2.2), must every applicable hazard statement text appear on the label and can statements be combined?

Yes — all applicable hazard statements must appear on the label, but they may be combined where appropriate as long as all hazards are still clearly conveyed. This is required by C.2.2 of Appendix C to 1910.1200.

  • C.2.2.1: The full text of applicable hazard statements should appear; combining statements is allowed to reduce clutter so long as none of the required hazard information is lost.
  • C.2.2.2: If the manufacturer/importer/responsible party can demonstrate a particular standardized statement is inappropriate for a specific substance or mixture, that statement may be omitted.

Document your basis for any omission or combination to support compliance.

Under 1910.1200(C.2.3.1), what are the required visual specifications for pictograms on labels?

Pictograms must be a square set at a point (diamond shape) with a black hazard symbol on a white background and a red frame sufficiently wide to be clearly visible. These graphic requirements are in C.2.3.1 of Appendix C to 1910.1200.

  • A red frame alone (just the diamond) without a hazard symbol is not a permitted pictogram.
  • Use one of the eight standardized hazard symbols shown in Appendix C’s Figure C.1 for the applicable hazard class (C.2.3.2).

Following these graphic specs ensures consistent, recognizable hazard communication.

Under 1910.1200(C.2.3.4), can the same pictogram appear multiple times on a label if it covers several hazards?

No — a pictogram may appear only once on a label even if multiple hazards trigger that same pictogram. This rule is stated in C.2.3.4 of Appendix C to 1910.1200.

  • If several hazards require the identical pictogram, include that pictogram a single time on the label.
  • If different hazard classes use the same pictogram, the single pictogram should still be present but the hazard statements and precautionary statements must cover all applicable hazards.

This prevents visual clutter while ensuring all hazards are communicated through accompanying text.

Under 1910.1200(C.2.3.3), when is the exclamation mark pictogram permitted for HNOC hazards and what text must accompany it?

The exclamation mark pictogram is allowed for HNOC hazards only if it is accompanied on the label by the words "Hazard Not Otherwise Classified" or the letters "HNOC." This permission is in C.2.3.3 of Appendix C to 1910.1200.

  • The exclamation mark pictogram alone is not sufficient for HNOC — the label must also include the required HNOC text to clarify that the hazard is not one of the standardized classes.
  • Use this only when a nonstandard health effect is identified that doesn’t map to the standardized hazard categories.

Including the HNOC wording avoids misleading users about the nature of the hazard.

Under 1910.1200(C.2.4.1–C.2.4.4), what are the four types of precautionary statements and how are optional phrases handled on labels?

Precautionary statements are grouped into four types — Prevention, Response, Storage, and Disposal — and optional phrases separated by a slash (/) indicate a choice where the manufacturer/importer/responsible party selects the most appropriate phrase. These rules are in C.2.4.1–C.2.4.4 of Appendix C to 1910.1200.

  • The bold core text in Appendix C is the default label text unless otherwise specified (C.2.4.1).
  • A slash (/) indicates the labeler can choose among the listed phrases (e.g., "Wear protective gloves/protective clothing/eye protection/face protection" can be shortened to the specific protective equipment needed) (C.2.4.2).
  • Use the most appropriate, non-diluted safety advice for your product and be consistent with the Safety Data Sheet.

Under 1910.1200(C.2.4.3), what do three dots (...) mean in precautionary statement text and how should a labeler use them?

Ellipses (...) indicate that not all applicable conditions are listed and that the labeler should specify other necessary items or conditions to complete the instruction. This is explained in C.2.4.3 of Appendix C to 1910.1200.

  • Example: "Use explosion-proof electrical/ventilating/lighting/.../equipment" means you must add any other equipment categories that are relevant (e.g., intrinsically safe equipment) when they apply.
  • The additional text selected must be accurate and help users follow safe procedures.

Do not leave ellipses unresolved on a label—fill in the needed specifics so the precaution is meaningful.

Under 1910.1200(C.2.4.5–C.2.4.6), how should italicized and bracketed text in precautionary statements be used on labels?

Italicized text in Appendix C is explanatory and generally should not appear on the label, while text in square brackets ([ ]) is optional and may be used only when certain conditions are met and additional information is provided at the point of use. These instructions appear in C.2.4.5–C.2.4.6 of Appendix C to 1910.1200.

  • Italics: Explain when or why a statement applies (e.g., "if dust clouds can occur") and are not intended as label text; they guide selection of the label text.
  • Brackets: Indicate conditional phrases such as "[In case of inadequate ventilation] wear respiratory protection," which you may use only if you supply clear information at the point of use describing what ventilation is adequate (C.2.4.5).

If you include bracketed text, make sure supporting details are available where the product is used so workers can follow the guidance correctly.

Under 1910.1200(C.2.4.7), can precautionary statement wording be slightly changed (for example spelling or synonyms) on labels?

Yes — minor textual variations such as spelling differences or synonyms are allowed if they help communicate safety information and do not dilute or compromise the prescribed safety advice; variations must be used consistently on the label and safety data sheet. This flexibility is stated in C.2.4.7 of Appendix C to 1910.1200.

  • Allowed changes include regional spelling (e.g., "colour" vs. "color") or simple synonyms that do not change meaning.
  • Consistency: use the same variation on both the label and the Safety Data Sheet so users see the same instructions.

Avoid wording changes that could lessen the clarity or effectiveness of the precaution.

Under 1910.1200(C.2.4.6–C.2.4.8), may precautionary statements be combined on a label, and are there limits?

Yes — precautionary statements may be combined or consolidated to save space and improve readability, provided the combined statement communicates the same safety advice and does not omit required information. This is allowed in C.2.4.6–C.2.4.8 of Appendix C to 1910.1200.

  • Example: "Keep away from heat, sparks and open flame" + "Store in a well-ventilated place" + "Keep cool" can be combined to "Keep away from heat, sparks and open flame and store in a cool, well-ventilated place." (C.2.4.6).
  • Do not combine in a way that hides or changes the required safety meaning.
  • Statements addressing different hazard classes usually remain independent unless a combined version still conveys each required precaution (C.2.4.8).

Use combinations only when they keep instructions clear and complete.

Under 1910.1200(C.2.4.9–C.2.4.10), when can a precautionary statement be omitted and how should multiple medical response statements be prioritized on a label?

A precautionary statement may be omitted if the manufacturer/importer/responsible party can demonstrate it is inappropriate for the specific substance or mixture, and where multiple medical response statements are triggered, prioritize and include the one reflecting the highest urgency with at least one route/symptom "IF" statement. See C.2.4.9–C.2.4.10 of Appendix C to 1910.1200.

  • Omission: You must be able to demonstrate why a standard precaution is not relevant to the material to justify leaving it off the label (C.2.4.9).
  • Medical responses: If multiple medical-response statements apply, include one statement at the highest urgency level and combine routes of exposure when appropriate; use "IF exposed or concerned" when three or more routes trigger similar responses (C.2.4.10(a),(b)).
  • Exception: "Get medical advice/attention if you feel unwell" and "Get immediate medical advice/attention" when used with an "If" statement must appear without prioritization.

Keep documentation that supports any omitted precautionary statement or your prioritization choices.

Under 1910.1200(C.3.1–C.3.2), may manufacturers or distributors add supplementary information on labels, and what are the limits?

Yes — manufacturers/distributors can add supplementary information on the label as long as it provides further detail, does not contradict or undermine the standardized hazard information, and does not impede identification of the required information. These limits are described in C.3.1–C.3.2 of Appendix C to 1910.1200.

  • Supplementary info must not cast doubt on the validity of signal words, hazard statements, pictograms, or precautionary statements.
  • Placement: supplemental text should not block or make required elements less visible (C.3.2).

Use extra information to help users safely handle the product, but keep standardized hazard content clearly prominent.

Under 1910.1200(C.3.3), when must a label and Safety Data Sheet state the percent of ingredients of unknown acute toxicity in a mixture?

When a mixture contains an ingredient with unknown acute toxicity at a concentration of 1% or greater, and the mixture is not classified based on testing of the whole mixture, the label and Safety Data Sheet must state the percentage of the mixture consisting of ingredients of unknown acute toxicity (oral/dermal/inhalation). This requirement is in C.3.3 of Appendix C to 1910.1200.

  • This statement helps downstream users and emergency responders understand potential unknown toxicity hazards.
  • The requirement applies when ingredient-level data are used for classification rather than whole-mixture testing.

Be specific about the percentage and which routes (oral, dermal, inhalation) apply to meet the labeling requirement.

Under 1910.1200(C.2.3.2) and Figure C.1, how many standard pictogram symbols are there and where are they defined?

There are eight standard hazard symbols defined for use on pictograms, and they are depicted in Figure C.1 of Appendix C to 1910.1200. This is stated in C.2.3.2 and Figure C.1.

  • The eight symbols cover common hazard classes such as Flame, Flame over Circle (oxidizers), Exclamation Mark, Exploding Bomb, Corrosion, Gas Cylinder, Health Hazard (silhouette), and Skull and Crossbones.
  • Use the symbol that corresponds to the specific hazard class/category listed in Appendix C.

Refer to Figure C.1 when selecting pictograms to ensure you use the standardized symbol for each hazard class.

Under 1910.1200(C.4.1), which pictogram and signal word correspond to Acute Toxicity—Oral categories 1–3 and category 4?

For Acute Toxicity—Oral categories 1–3 the pictogram is the Skull and Crossbones and the signal word is "Danger"; for category 4 the pictogram is the Exclamation Mark and the signal word is "Warning." These assignments are shown in C.4.1 of Appendix C to 1910.1200.

  • Categories 1–3: Hazard statement examples include "Fatal if swallowed" with "Danger" and the skull-and-crossbones pictogram.
  • Category 4: Hazard statement example is "Harmful if swallowed" with "Warning" and the exclamation mark pictogram.

Use the category-specific signal word, pictogram, hazard statement, and appropriate precautionary statements when labeling acute toxicity hazards.

Under 1910.1200(C.2.2.2), when can a hazard statement be omitted from a label because it is inappropriate?

A hazard statement may be omitted if the chemical manufacturer, importer, or responsible party can demonstrate that the standardized hazard statement (or part of it) is inappropriate for the specific substance or mixture. This allowance is in C.2.2.2 of Appendix C to 1910.1200.

  • You must have a documented scientific or technical basis showing why the statement is not applicable to the specific material.
  • Keep records of the rationale and any supporting data in case compliance verification is requested during inspections.

Omissions should be conservative and well-justified to avoid failing to communicate necessary hazards.

Under 1910.1200(C.3.2), how should supplemental label information be placed so it doesn't interfere with required elements?

Supplementary information must be placed so it does not impede identification of the required standardized information (signal word, hazard statements, pictograms, precautionary statements). This placement guidance is in C.3.2 of Appendix C to 1910.1200.

  • Keep required elements prominent and immediately visible to the label reader.
  • Place supplemental details in a location that is clearly separate or subordinate to the standardized hazard zone so they do not dilute or obscure required warnings.

Design labels so users can rapidly find and read the required hazard information first.

Under 1910.1200(C.2.4.10), what general principles apply when multiple health hazards trigger several medical response precautionary statements?

When multiple health hazards trigger several medical-response precautionary statements, prioritize the statements and include the one with the highest urgency combined with at least one route-of-exposure or symptom "IF" statement; combine routes when appropriate and use "IF exposed or concerned" if three or more routes are triggered. These principles appear in C.2.4.10 of Appendix C to 1910.1200.

  • (a) Use prioritization: include one medical-response statement at the highest urgency, and add at least one route/symptom-related "IF" clause.
  • (b) Routes of exposure may be combined; if three or more routes trigger the same response, you may use "IF exposed or concerned."
  • (c) Do not prioritize the phrases "Get medical advice/attention if you feel unwell" or "Get immediate medical advice/attention" when they include an "If" clause; those must appear without prioritization.

Apply these rules so medical guidance on the label is clear and actionable in an emergency.

Under 1910.1200(C.2.4.10(c)), are statements like "Get immediate medical advice/attention" subject to prioritization?

No — the phrases "Get medical advice/attention if you feel unwell" and "Get immediate medical advice/attention" when used with an "IF" statement must appear without prioritization and may not be reduced by the prioritization rules. This requirement is explained in C.2.4.10(c) of Appendix C to 1910.1200.

  • These statements are considered critical medical-response directions that cannot be omitted or subordinated when triggered.
  • Include them exactly as required and ensure at least one route or symptom "IF" clause accompanies them when specified.

Treat these medical-response statements as mandatory where they apply.

Under 1910.1200(C.2.4.1 example in C.4.1), can labels instruct users about specific body parts to wash after handling, and where does that guidance appear?

Yes — labels can (and in some cases must) direct users to wash specified body parts after handling; Appendix C indicates the chemical manufacturer/importer/distributor should specify which parts of the body to wash and the appropriate emergency medical source. This guidance is illustrated in C.4.1 and related text in Appendix C to 1910.1200.

  • Example: "Wash hands and forearms thoroughly after handling" or other specific instructions are used to tailor first-aid and prevention advice to the product.
  • The label should also tell users who to contact in an emergency (e.g., "Call a poison center/doctor...") and reference supplemental first-aid instructions when needed.

Provide clear, specific washing and first-aid instructions so users know what actions to take after exposure.

Under 1910.1200AppC and C.2.2.1, may hazard statements be shortened to improve readability, and what is the limit?

Hazard statements may be combined or shortened to improve readability, but the combined text must still convey all required hazard information without omission. This is allowed under C.2.2.1 of Appendix C to 1910.1200.

  • Combining is intended to reduce label clutter as long as every applicable hazard is still communicated.
  • Any omitted words must not change the meaning or lessen the warning's protective effect.

If you compress or combine statements, verify that the revised wording still meets Appendix C’s standardized hazard communication objectives.

Under 1910.1200 App C, when should a label tell users to "Immediately call a poison center/doctor/..."?

A label should say "Immediately call a poison center/doctor/..." when the substance can produce serious or urgent health effects that require immediate medical advice or treatment. Under 1910.1200 App C, the Appendix shows that for acute toxic and corrosive hazards the response/preparedness block includes the instruction to contact a poison center or doctor immediately when exposure may cause serious harm.

  • Include this instruction when first-aid guidance or rapid medical intervention (for example, an antidote or other urgent treatment) is listed on the label.
  • The label should also identify the appropriate source of emergency medical advice (who to call) as the manufacturer/importer/distributor specifies.

Reference: 1910.1200 App C.

Under 1910.1200 App C, can a manufacturer specify a cleansing agent other than water for skin decontamination?

Yes. A manufacturer may specify a particular cleansing agent if appropriate, and may recommend an alternative when water is clearly inappropriate. The Appendix examples show that manufacturers, importers, or distributors may name a specific cleanser on the label when water is not the correct immediate treatment.

  • Use a specified cleansing agent only if it is appropriate for the chemical and safe for first‑aid use.
  • If water is inappropriate, the label should explain the alternative and reference any supplemental first‑aid instructions.

Reference: 1910.1200 App C.

Under 1910.1200 App C, when must a label tell users to "Take off immediately all contaminated clothing and wash it before reuse"?

Labels must include "Take off immediately all contaminated clothing and wash it before reuse" when skin contact with the chemical can lead to penetration, absorption, or continued exposure from contaminated clothing. The Appendix sample precautionary statements for dermal hazards and corrosives show this exact response statement to prevent ongoing exposure.

  • Include this instruction when a chemical can cause skin burns, irritation, or toxic systemic effects through skin contact.
  • The manufacturer should also provide any additional washing instructions or specify laundering precautions if needed.

Reference: 1910.1200 App C.

Under 1910.1200(C.4.2), what pictogram, signal word, and hazard statement are used for acute dermal toxicity Category 3 and Category 4?

For acute dermal toxicity Category 3 the label should use the Skull and Crossbones pictogram, the signal word "Danger," and the hazard statement "Toxic in contact with skin." For Category 4 the label should use the Exclamation Mark pictogram, the signal word "Warning," and the hazard statement "Harmful in contact with skin."

Reference: 1910.1200(C.4.2).

Under 1910.1200(C.4.3), which pictograms and signal words apply to acute inhalation toxicity categories 1–4?

Acute inhalation toxicity categories 1 and 2 use the Skull and Crossbones pictogram with the signal word "Danger" and hazard statement "Fatal if inhaled." Category 3 also uses the Skull and Crossbones with "Danger" and "Toxic if inhaled." Category 4 uses the Exclamation Mark pictogram with the signal word "Warning" and "Harmful if inhaled."

  • These category-specific examples and corresponding pictograms appear in 1910.1200(C.4.3).

Reference: 1910.1200(C.4.3).

Under 1910.1200(C.4.3), what prevention statements are appropriate for inhalation hazards and when may bracketed text be used?

Prevention statements for inhalation hazards should tell users to avoid breathing dust/fume/gas/mist/vapors/spray and to use the chemical outdoors or in a well-ventilated area when appropriate. Bracketed text such as "[In case of inadequate ventilation] wear respiratory protection" may be used only if the label is complemented at the point of use by additional information explaining what ventilation is adequate for safe use.

  • Use the unbracketed prevention text when general ventilation controls suffice.
  • Use the bracketed respiratory protection text only when you can provide clear, specific conditions and controls at the workplace that justify it.

Reference: 1910.1200(C.4.3).

Under 1910.1200(C.4.3), what response instructions should a chemical label give if someone is inhaled?

If someone has been exposed by inhalation, the label should instruct to remove the person to fresh air and keep them comfortable for breathing, and to call a poison center/doctor immediately if the exposure is serious. The Appendix examples for inhalation hazards include both the "If inhaled: Remove person to fresh air and keep comfortable for breathing" response and the instruction to get urgent medical help.

  • For very hazardous chemicals, labels may direct immediate specific treatment and to reference supplemental medical instructions on the label.

Reference: 1910.1200(C.4.3).

Under 1910.1200 App C, when must the corrosive pictogram and the hazard statement "corrosive to the respiratory tract" be used?

The corrosive pictogram and the hazard statement "corrosive to the respiratory tract" must be used when skin or eye data indicate that the chemical could be corrosive to the respiratory tract and cause lethality. The Appendix notes that if the classifier determines, based on skin or eye data, that the substance may be corrosive to the respiratory tract leading to lethality, the corrosive hazard must also be communicated with the corrosive pictogram and that specific hazard statement.

  • Apply this in addition to any other applicable acute toxicity or corrosivity communication on the label.

Reference: 1910.1200 App C and 1910.1200(C.4.3).

Under 1910.1200(C.4.4), what first-aid steps should be on the label for skin corrosion or severe burns?

For skin corrosion or severe burns the label should say to take off immediately all contaminated clothing and rinse the skin with water or shower, and to wash contaminated clothing before reuse; it should also direct that a poison center/doctor be called immediately in serious cases. The Appendix examples for skin corrosion/irritation include the instructions to remove contaminated clothing, rinse with water or shower, and launder contaminated clothing prior to reuse.

  • Include any specific treatment information or supplemental first-aid instructions where immediate measures (e.g., a particular cleanser or antidote) are required.

Reference: 1910.1200(C.4.4).

Under 1910.1200(C.4.5), what should labels say for eye exposure first aid?

Labels should instruct to rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, and continue rinsing; for serious exposures they should direct to call a poison center or doctor immediately. The Appendix examples for eye damage/irritation contain the specific wording to rinse eyes for several minutes and to remove contact lenses if easy to do, and to seek urgent medical advice when required.

  • If special treatment or antidotes are necessary, the label should reference the supplemental first‑aid information.

Reference: 1910.1200(C.4.5).

Under 1910.1200 App C, who must specify the type of protective gloves or equipment on a chemical label?

The chemical manufacturer, importer, or distributor must specify the appropriate type of protective gloves or other personal protective equipment on the label when that level of specificity is necessary for safe use. The Appendix precautionary statements show the instruction "Wear protective gloves/protective clothing" with a note that the manufacturer/importer/distributor should specify the type of equipment where appropriate.

  • Specify glove material or other PPE only when generic advice (e.g., "wear gloves") is insufficient to protect against the chemical hazard.

Reference: 1910.1200 App C.

Under 1910.1200 App C, when should a label include "Store in a well-ventilated place" or "Keep container tightly closed"?

Labels should say "Store in a well-ventilated place" and/or "Keep container tightly closed" when the chemical is volatile or may generate a hazardous atmosphere; the Appendix examples for inhalation hazards show these storage statements used for volatile or inhalation‑hazardous chemicals.

  • Use "Keep container tightly closed" when preventing vapors or emissions is important.
  • Use "Store in a well-ventilated place" when ventilation is necessary to avoid buildup of hazardous concentrations.

Reference: 1910.1200(C.4.3).

Under 1910.1200 App C, when should a label say "Store locked up"?

A label should include "Store locked up" when the chemical requires controlled access to prevent accidental exposure, misuse, or access by the public, as shown in multiple Appendix examples where "Store locked up" is listed in the storage precautionary statements.

  • Use this statement for highly hazardous or restricted chemicals where secure storage is part of safe handling.

Reference: 1910.1200 App C.

Under 1910.1200 App C, what disposal wording must appear and who decides whether it applies to the contents, the container, or both?

Labels should include disposal instructions such as "Dispose of contents/container to... in accordance with local/regional/national/international regulations" and the chemical manufacturer, importer, or distributor must specify whether the disposal requirement applies to the contents, the container, or both. The Appendix explicitly states the manufacturer/importer/distributor must indicate which disposal requirements apply.

  • Tailor the disposal phrase to reflect applicable regulations and to make clear if the container is empty, rinsed, or still hazardous.

Reference: 1910.1200 App C.

Under 1910.1200(C.4.3), when may a label instruct users to "Use only outdoors or in a well-ventilated area" versus requiring respiratory protection?

A label should say "Use only outdoors or in a well-ventilated area" when adequate ventilation will prevent harmful inhalation exposures; it should indicate respiratory protection (for example, "[In case of inadequate ventilation] wear respiratory protection") only when ventilation may be insufficient and the manufacturer can provide additional information about what ventilation is required at the point of use.

  • Prefer ventilation controls first; list respirators only as backup when you can specify the conditions that make ventilation inadequate.

Reference: 1910.1200(C.4.3).

Under 1910.1200AppC, can a product label omit a pictogram (for example, Eye Irritation category 2B shows "No Pictogram")?

Yes — some hazard categories in Appendix C are shown without a pictogram and a label may not include a pictogram when the classification and Appendix C example indicate "No Pictogram." See the example for Eye Damage/Irritation (Category 2B) in 1910.1200AppC and the specific Eye Damage/Irritation entry at 1910.1200(C.4.5)

  • The absence of a pictogram in Appendix C means the standard example for that specific hazard category does not require a pictogram; it does not remove other label requirements (signal word, hazard statement, and precautionary statements).
  • Manufacturers, importers, or distributors must still provide the appropriate hazard statement (e.g., "Causes eye irritation"), signal word, and applicable precautionary statements as shown in the Appendix C example.
  • Always check the full Hazard Communication standard 1910.1200 for general labeling obligations and any updates.

Under 1910.1200(C.4.6), what must a label for Respiratory Sensitization include?

The label must present the Health Hazard pictogram, the signal word "Danger," the hazard statement that it "May cause allergy or asthma symptoms or breathing difficulties if inhaled," and the appropriate prevention and response precautionary statements shown in Appendix C. See 1910.1200(C.4.6) for the example.

  • Prevention language often includes: "Avoid breathing dust/fume/gas/mist/vapors/spray" and, if applicable, the bracketed text "[In case of inadequate ventilation] wear respiratory protection." The manufacturer/importer/distributor must specify the applicable conditions or equipment.
  • Response language typically includes: "If inhaled: If breathing is difficult, remove person to fresh air and keep comfortable for breathing" and instructions to call a poison center/doctor if respiratory symptoms occur (manufacturer to identify the appropriate medical source).
  • For full labeling duties and classification references see the general rule at 1910.1200.

Under 1910.1200(C.4.7), what precautionary statements are expected on a label for Skin Sensitization?

A label for Skin Sensitization should include the Exclamation Mark pictogram, the signal word "Warning," the hazard statement "May cause an allergic skin reaction," and prevention/response items such as avoiding breathing dust/fume/gas/mist/vapors/spray, not allowing contaminated work clothing out of the workplace, and wearing protective gloves. See the Appendix C example at [1910.1200(C.4.7)](https://www.osha.gov/laws-regs/regulations/standardnumber/1910/1910.1200#1910.1200(C.4.7).

  • Typical prevention statements: "Contaminated work clothing must not be allowed out of the workplace" and "Wear protective gloves." The label-maker should specify glove type when appropriate.
  • Typical response statements: "If on skin: Wash with plenty of water/..." and "If skin irritation or rash occurs: Get medical advice/attention." Manufacturers may reference supplemental first-aid instructions on the label.
  • These label elements are examples from Appendix C; the full labeling rules are in 1910.1200.

Under 1910.1200AppC, when should a chemical label include the instruction "Store locked up"?

You should include "Store locked up" on the label when Appendix C's examples for certain hazards call for it — most commonly for some Carcinogenicity and Reproductive Toxicity categories. See the Carcinogenicity example at 1910.1200(C.4.9) and the Reproductive Toxicity example at 1910.1200(C.4.10).

  • Appendix C provides example label text; where it prescribes storage statements such as "Store locked up," the manufacturer, importer, or distributor should include that instruction when the hazard classification corresponds to the example.
  • Including "Store locked up" is a control measure to limit access and reduce exposure for particularly hazardous substances (e.g., certain carcinogens or reproductive toxicants).
  • For the overall labeling obligation consult the main Hazard Communication rule at 1910.1200.

Under 1910.1200(C.4.8), what must a label for Germ Cell Mutagenicity include?

A Germ Cell Mutagenicity label must include the Health Hazard pictogram, an appropriate signal word ("Danger" for Category 1A/1B; "Warning" for Category 2), the hazard statement (for example, "May cause genetic defects"), and prevention/response instructions such as "Obtain special instructions before use" and PPE requirements. See the Appendix C example at 1910.1200(C.4.8).

  • Prevention examples: "Obtain special instructions before use" and "Do not handle until all safety precautions have been read and understood." The manufacturer/importer/distributor should specify the appropriate PPE (gloves, eye/face protection, etc.).
  • Response example: "If exposed or concerned: Get medical advice/attention." The label must direct users to an appropriate medical source as specified by the supplier.
  • For classification and labeling obligations refer to the main Hazard Communication standard at 1910.1200.

Under 1910.1200AppC, what is the concentration threshold that requires both a label and an SDS for a Category 2 carcinogen ingredient in a mixture?

If a Category 2 carcinogen ingredient is present in a mixture at a concentration greater than 1%, then both a Safety Data Sheet (SDS) and a label are required and the information must be included on each. This requirement is stated in Appendix C; see 1910.1200AppC and the specific note in the Carcinogenicity section at 1910.1200(C.4.9).

  • The >1% threshold in Appendix C is the example-specific guidance for Category 2 carcinogens; follow the main 1910.1200 requirements for SDS and labeling obligations.
  • If you prepare or use mixtures near this threshold, document your concentration determinations and ensure the SDS and label reflect the required hazard information.
  • When in doubt about classification or concentration, consider consulting a qualified toxicologist or regulatory specialist to confirm obligations under 1910.1200.

Under 1910.1200(C.4.11), how should labels communicate Specific Target Organ Toxicity (single exposure) and when is the corrosive-to-respiratory-tract note used?

Labels for Specific Target Organ Toxicity (single exposure) must follow the Appendix C examples: Category 1 uses the Health Hazard pictogram and the signal word "Danger" with the hazard statement "Causes damage to organs..."; Category 2 uses the Health Hazard pictogram with "Warning" and "May cause damage to organs..."; Category 3 commonly uses the Exclamation Mark pictogram with "Warning" and "May cause respiratory irritation; or May cause drowsiness or dizziness." See 1910.1200(C.4.11).

  • Appendix C also states: if the substance/mixture is determined to be corrosive to the respiratory tract, the label must communicate "corrosive to the respiratory tract, if inhaled" and use the corrosive pictogram instead of the usual STOT pictogram and hazard statement.
  • Prevention, response, storage, and disposal phrases shown in Appendix C should be used as applicable (for example, "Do not breathe dust/fume/gas/mist/vapors/spray," and "Store locked up" where specified).
  • Follow the general Hazard Communication rules in 1910.1200 for classification and labeling details.

Under 1910.1200AppC, who chooses the specific medical advice wording on a label (for example, "Call a poison center/doctor/ ...") and what is required of that wording?

The chemical manufacturer, importer, or distributor selects the specific medical advice or attention wording on the label and must identify an appropriate source of emergency medical advice (for example, "Call a poison center/doctor/...") as shown in multiple Appendix C examples. See examples such as 1910.1200(C.4.6) and 1910.1200(C.4.11).

  • The supplier must choose wording that accurately directs exposed persons to the correct medical resource (poison center, physician, emergency services, etc.) for that substance and use-case.
  • Where Appendix C uses ellipses or parenthetical notes (e.g., "Call a poison center/doctor/..."), the supplier must fill in the blank with the appropriate contact or instruction for that product.
  • Ensure the chosen medical contact is available and appropriate for the likely exposures; document the decision in your hazard communication program under 1910.1200.

Under 1910.1200AppC, what instructions about contaminated clothing are typically shown on labels and who decides the exact wording?

Appendix C examples commonly instruct that contaminated clothing "must not be allowed out of the workplace" and that contaminated clothing should be removed and washed before reuse; the chemical manufacturer, importer, or distributor selects and may modify the exact wording as appropriate. See the Skin Sensitization example at 1910.1200(C.4.7) and the Germ Cell Mutagenicity/Other entries in 1910.1200AppC.

  • Typical label instructions: "Contaminated work clothing must not be allowed out of the workplace" and "Take off contaminated clothing and wash it before reuse." Suppliers may specify cleaning methods or exceptions where water is inappropriate.
  • Employers should translate label directions into workplace procedures (laundry, containment, disposal) and train employees on handling contaminated clothing per 1910.1200.
  • If a label references a specific cleansing agent or special handling, the supplier must ensure that instruction is appropriate and accurate for the chemical in question.

Under 1910.1200AppC, when should a label explicitly state the route of exposure (for example, "state route of exposure if no other routes of exposure cause the hazard")?

A label should state the route of exposure when the Appendix C example or the classification requires it — specifically when the hazard exists only by a particular route and no other routes cause the hazard (for example, certain germ cell mutagenicity or carcinogenicity entries include that instruction). See entries such as 1910.1200(C.4.8) and 1910.1200(C.4.9).

  • The parenthetical note "(state route of exposure if no other routes of exposure cause the hazard)" tells suppliers to add the specific route (e.g., "if swallowed," "if inhaled") when that route is the sole relevant pathway for the hazard.
  • If multiple routes contribute to the hazard, use the generic hazard statement without limiting to a single route; follow the classification guidance in 1910.1200 and Appendix A for determining routes and statements.
  • When preparing labels, document your rationale for any route-specific wording so employers and emergency responders can understand the exposure pathway.

Under 1910.1200(C.4.12) (Specific Target Organ Toxicity — Repeated Exposure), what label elements are required for Category 1 and Category 2 hazards (signal word, pictogram, hazard statement, and typical precautionary statements)?

Labels for repeated-exposure target organ toxicity must include the Health Hazard pictogram, the appropriate signal word ("Danger" for Category 1; "Warning" for Category 2), and a hazard statement that names the organs affected; they must also include suitable prevention and response precautionary statements as shown in Appendix C. See 1910.1200(C.4.12) and Appendix C to 1910.1200 for the official examples and format.

  • Key label elements (from Appendix C):
    • Pictogram: Health hazard (the silhouette with starburst). See Appendix C.
    • Signal word: "Danger" for Hazard Category 1; "Warning" for Hazard Category 2.
    • Hazard statement: Category 1 — "Causes damage to organs through prolonged or repeated exposure (state organs affected, if known)"; Category 2 — "May cause damage to organs through prolonged or repeated exposure (state organs affected, if known)." (Appendix C shows the wording and instructs manufacturers to state specific organs when known.)
    • Prevention examples: "Do not breathe dust/fume/gas/mist/vapors/spray." and "Wash ... thoroughly after handling." (manufacturers specify applicable conditions and body parts to be washed).
    • Response example: "Get medical advice/attention if you feel unwell." (manufacturers select whether to advise medical advice or medical attention as appropriate).

Practical notes:

  • The label should explicitly name all organs known to be affected (e.g., "Causes damage to the liver and kidneys"). Appendix C requires stating affected organs when known; see 1910.1200(C.4.12).
  • Follow the overall Hazard Communication standard requirements in 1910.1200 when preparing labels (signal word, pictogram, hazard statement, precautionary statements, and supplier identification).

Under 1910.1200(C.4.13) (Aspiration Hazard), what must a warning label say and what immediate first-aid response language should be on the label for a Category 1 aspiration hazard?

For an Aspiration Hazard Category 1, the label must use the Health Hazard pictogram, the signal word "Danger," and the hazard statement "May be fatal if swallowed and enters airways"; it must also include a response instruction that tells users to seek prompt medical help and not to induce vomiting. See 1910.1200(C.4.13) and Appendix C to 1910.1200 for the official example.

  • Required label elements for Category 1 aspiration hazard (per Appendix C):
    • Pictogram: Health hazard.
    • Signal word: Danger.
    • Hazard statement: "May be fatal if swallowed and enters airways."
    • Response example: "If swallowed: Immediately call a poison center/doctor/..." and explicit instruction "Do NOT induce vomiting." (the manufacturer/importer/distributor must specify the appropriate source of emergency medical advice).
    • Storage example: "Store locked up." (Appendix C shows "Store locked up." as a storage precaution for aspiration hazards.)

Practical guidance:

  • Make the response wording specific enough for emergency action (for example, name the poison center phone number or local emergency number if applicable) as Appendix C expects suppliers to specify the appropriate source of emergency medical advice; see 1910.1200(C.4.13).
  • Ensure the full label set (signal word, pictogram, hazard statement, precautionary statements, and supplier ID) complies with the overall Hazard Communication standard at 1910.1200.